Dr Daniyal Jafree is an early-career clinician-scientist, working as an Academic Foundation Year 1 (FY1) Doctor in the East of England Deanery, whilst serving as a part-time Postdoctoral Research Fellow at University College London (UCL), supported by a Foulkes Foundation fellowship.
Dr Jafree completed a PhD in the Developmental Biology & Cancer Program at UCL Great Ormond Street Institute of Child Health (GOSICH) supervised by Prof David Long. His recent scientific contributions have been at the intersection of vascular biology and organ development and disease, where we developed workflows for wholemount immunolabelling, optical clearing and three-dimensional 3D imaging of intact biological tissues (Jafree et al. Methods Mol Biol. 2020) which have been used to decipher how the lymphatic vasculature of the kidney develops in mouse and human embryos (Jafree et al. eLife 2019; Jafree et al. J Am Soc Nephrol. 2020).
Dr Jafree is now applying 3D imaging, single-cell RNA sequencing and in vivo imaging modalities of genetically engineered mice or patient samples to study the vasculature in renal pathology and cancer.
He has experience in a wide variety of biomedical research techniques including mouse husbandry, PCR, flow cytometry, histology and immunohistochemistry, advanced imaging techniques including confocal and two-photon microscopy, lightsheet fluorescence microscopy and high resolution episcopic microscopy and computational techniques including the analysis of single-cell RNA sequencing data and 3D image analysis.
Dr Jafree’s ambition is to combine his scientific background with his clinical commitments to generate a programme of work deciphering the role of the vasculature in human health, inflammation, and malignancy and to exploit the vasculature as a therapeutic target for patient benefit.